Mosby's FAQ
Grapeseed Extract Defined

  • "Reported Use
    Grapeseed may be used as an antioxidant and an anticancer treatment; to treat varicose veins and circulatory problems; and to treat
    vision problems such as cataracts and improve vision by lessening eye strain.

  • Investigational Use
    Researchers are experimenting with the use of grapeseed to treat diabetes mellitus and degenerative, diverticular, and heart diseases.

  • Product Availability and Dosages
    Available Forms - capsules, tablets
    Plant parts used - seeds
    Dosages and Routes - are standardized to 85% - 95% procyanidins.  
    Adult - Supplementation PO (by mouth) capsules/tablets: 50-100 mg qd (milligrams every day), (McCaleb, 2000).  
    Therapeutic Use - PO capsules/tablets: 150-300 mg eq (milligrams every day) for 21 days, then 50-80 mg eq (milligrams every day)
    maintenance (McCaleb, 2000)

  • Precautionary Information
    Contraindications: Until more research is available, grapeseed should not be used during pregnancy or and lactation and should not be
    given to children.

  • Side Effects/Adverse Reactions
    Central Nervous System: Dizziness
    Gastrointestinal: Nausea, anorexia, Hepatotoxicity (theoretical)
    Integumentary: Rash

  • Interactions
    Herb/Drug - unknown
    Herb/Food - unknown
    Herb/Herb - unknown

  • Client Considerations
    Assess - If the client is using grapeseed to improve cardiovascular disorders, assess cardiovascular status: edema in legs, improvement
    in atherosclerosis, improvement in varicose veins.  Monitor blood pressure and pulse.
    Identify other cardiovascular medications taken by the client.
    Assess for hepatotoxicity..

  • Administer
    Instruct the client to take grapeseed PO only once per day.
    Instruct the client to store grapeseed products in a cool, dry place, away from heat and moisture.

  • Teach Client/Family
    Until more research is available, caution the client not to use grapeseed during pregnancy and lactation and not to give it to children.

  • Pharmacology
    Pharmacokinetics and pharmacodynamics are unknown.

  • Primary Chemical Components of grapeseed and Their Possible Actions -
  • Chemical Class: Flavonoid, Tannin, Tocopherol, Fatty acid
  • Individual Component: Kaempferol, Quercetin, Proanthocyanidins
  • Possible Action: Anti inflammatory
  • Actions
    Vision Improvement - Grapeseed has produced beneficial effects in people with vision problems.  One study focused on participants
    with computer related visual stress.  People who worked at a video display terminal (VDT) for at least 6 hours a day were assigned to
    one of three groups, receiving either grapeseed, bilberry, or a placebo.  After 2 months, the grapeseed group reported much less
    visual stress, with improvements even greater than those seen in the bilberry group (Fusi, 1990).  An earlier study had shown grapeseed
    to be significantly more effective than a placebo in improving night vision.  This earlier study included 98 people who experienced
    prolonged night visual glare or visual stress caused by VDT's (Corbe, 1988).

  • Other Actions
    Grapeseed has shown protective effects against carbon tetrachloride hepatic poisoning in mice (Oshima, 1995).

  • References
    Corbe CH et al: Chromatic sense and chorioretinal circulation: a study of effects of OPC (Endotelon), ... " see book for the rest...

  • About The Mosby's Handbook
  • This book can be purchased from Barnes and Noble.

  • Disclaimer / Considerations / Recommendations
    We make no medical claims or guarantees on how these products will work.  We highly recommend  you conduct your own
    research.  Results may vary with individual and dosage.
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Mosby's Hand Book of Herbs & Natural Supplements,
Linda Skidmorer-Roth, RN, MSN, NP, Copyright 2001 by Mosby, Inc.
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